Abstract: A comprehensive research on spatial analysis for the highrise-pile foundation-soil interaction was carried out. The coeffieients of the stress distributions are evaluated for determining the deformation of the soil medium, in which the pile-soil interaction is taken into account. The running speed and the accuracy are extremely improved after the analytical expression of the coefficient end of the stress distribution were introduced. The interaction equation and the universal program of the whole system were also established, which makes it possible to accomplish the spatial analysis of the highrise-pile-soil interaction. The effects, such as the floor-by-floor erection of the highrise, the variation of the stiffness of the plate, the change of the soil formation and the pile spacing on the settlement and stresses in the pile, the pile loads and the stresses in the superstructure were also analysed. Several useful rules of the interaction were also concluded.