Abstract: ：The effect of the reconstructed highways on the existing nearby projects is a critical technical issue. Aiming at the extension project of Xiangcheng highway in Suzhou which crosses under Beijing-Shanghai high-speed railway, a three-dimensional model for the high-speed railway pile groups and highway pile groups is established, and then FEM is used to analyze this problem. The complete constructing procedure and the operation period loads are considered. The negative friction, axial force and lateral deformation of high-speed railway piles are taken as the research subjects, and the pattern and magnitude of the effects on the high-speed railway piles are revealed thoroughly. Two construction schemes of pile groups in the highway are compared. It may provide technical support for the optimization of the design plan and the construction scheme of the pile groups in highway and reference for the similar projects.