Abstract: For the project of large-diameter shield tunnel under the highest water pressure in China, a set of design process and research method is proposed for the waterproof gasket for segment joints, and the related pattern is studied. First of all, based on the worldwide research progress, combined with the engineering characteristics, a double seal elastomer arrangement for segment joint waterproof gasket of large-diameter shield tunnel under the ultra high water pressure is determined. Secondly, the technical standard of waterproof is studied, and it lays the basis for further analysis of the elastic gasket design and experiment. Thirdly, comparative analysis of several sections of elastic seal gaskets is performed. Finally, a set of unique device and method is adopted, performing the experiments on the waterproof ability and assembly force of the gaskets, and through the comprehensive analysis of the experiment data, the optimal design scheme of the waterproof gasket for segment joint is determined.