Abstract: The water-rock (soil) interaction is closely related to the formation of landslides hazards. Huangtupo riverside landslide, which locates in the district of Three Gorges Reservoir, and is still in the process of intense deformation, is chosen as the research landslide. 8 kinds of unfavorable geologic bodies (including soft rock layer, sliding soil and weak intercalation ) are collected from different parts of the landslide, and these samples are employed to track and test the mineral type and content, chemical composition and particle size distribution and other indicators. After analysis, 8 kinds of unfavorable geologic bodies have an obvious homeology; and in the water-rock (soil) interaction, the formation and transformation processes of the main unfavorable geologic elements can be clearly presented. Afterward, based on a number of rock and soil samples collected near the main slip zone along the vertical direction and combined with test data, in-depth analysis and visual display of how the water-rock (soil) interaction affects rock and soil microstructure and weakens the mechanical properties are performed. The water-rock (soil) interaction mechanism of Huangtupo riverside landslide is studied in depth, and it can provide important references for finding out the formation process of similar landslide hazards and preparing landslide prevention programs.