Abstract: Non-conforming deformation feature between pile foundation and canal slope in the total main canal of the Middle Route project of China's South-to-North Water Division is the main technical problem which should be solved before the construction. In order to design effective and rational impervious structure in the combination part, an ABAQUS numerical model is established to simulate the non-conforming feature between pile and canal slope. An engineering example of the non-conforming deformation is calculated and analyzed. The result shows that the proposed model can satisfactorily simulate the development process of the non-conforming deformation between pile and soil body of canal slope, and with the increase of horizontal load, the crack depth gradually increases and can even reach 1/2 of the pile length under the soil surface. Under the small vertical load, there is no slip deformation between pile and soil, and with the increase of the vertical load the settlement of the pile increases from linear to nonlinear segment, and the settlement of soil adjacent to the pile is basically in a linear increase. Under the horizontal load, the situation is different, even small horizontal load will cause separation deformation between pile and soil, when the load increases, the horizontal displacement of pile nonlinearly increases, but that (spring displacement) of the soil adjacent to the pile is basically in a linear increase. According to the case study, the non-conforming deformation is relatively small under actual load. So in the preliminary design, asphalt sealing measures can adapt to the non-conforming deformation basically, and they prevent the infiltration of rainwater and water drainage.