Abstract: Experimental researches on a large-scale(1:2) in-situ model test of layered soil-box foundation-structure system to study the dynamic interaction under explosive earthquake waves were carried out.By applying a secondary development to ANSYS with multi-transmitting boundary,the effects of artificial transmitting boundary(ATB),property of backfilled soil,the weak intercalation and main frequency range on superstructure were comprehensively investigated.Compared with the results of fixed soil boundary and fixed base boundary,the results of ATB agreed well with the test results.Stiffness variation of backfilled soil played a small role on superstructure response when the substratum was relative stiff and the box foundation embedment was shallow.The weak intercalation could reduce the seismic response of superstructure.Acceleration and damage of superstructure under low frequency earthquake was larger than that under high frequency blast earthquake.At the same time,in some special cases,the computed results under the fixed base assumption were not always on the safeside.