Abstract: Analysis on earthquake-induced differential settlement of an actual building was accomplished by using the simplified method proposed by authors.The combined effect of the soil,structure and seismic wave was considered in the analysis and the time-dependant curves of earthquake-induced differential settlement of the building were obtained according to differential probability of seismic ground motion.The present results provide the basis for a seismic design of the building and the reference for evaluation of the safety of other important building during earthquakes.