Abstract: Dynamic design and informaticsized construction ar e the new developing technology.Because of particularity and complex ity of Qinghai-Tibet railway c onstruction, the technology of the dynamic design and informaticsized constructi on was used tentatively. Based on processes of Qinghai-Tibet railway constructi on, t his paper discussed and analysed the idea of dynamic design and its applications . Me anwhile in allusion to raise problems in design and construction, some principl es and suggestions of reinforcing measures were put forward. Good effects of this technology have been ob tained in the construction and design of Qinghai-Tibet railway.