Abstract: As a new slope reinforcement method, the prefabricated prestressed anchor cable frame has been used in engineering. However, its seismic performance still needs to be studied deeply. Based on a practical project, a nonlinear dynamic time history numerical model is established for the reinforcement of slope by the combination of "cross beam" and "straight beam" using El Centro waves as the ground motion input. The influence rules of different earthquake intensities are analyzed through amplitude modulation. The results show that the horizontal displacement difference of the slope after the reinforcement of the frame beams decreases significantly. The influences of the peak acceleration on the horizontal displacement of the slope are mainly reflected at the residual deformation stage. The permanent displacement of the slope after earthquake increases with the increasing peak acceleration, and the growth rate is gradually accelerated. Under different peak accelerations, the slope acceleration response has a certain lag effect. When the peak acceleration is large, the slope acceleration response is in a state of drastic fluctuation for a long time. After reinforcement, the acceleration amplification coefficient can reach 8.0, and gradually decreases with the increase of earthquake intensity. The maximum stress at the bottom of the prefabricated cross beams is obviously smaller than that of the prefabricated straight ones. When the peak acceleration is 0.4g, the bottom of the frame beams has the risk of cracking.