Abstract: The prestressed anchor cable is an important component of the anti-slide pile of prestressed anchor cable, but the influences of its arrangement angle on the seismic performance of the anti-slide pile of prestressed anchor cable is not yet clear. To this end, a series of centrifugal model tests considering the horizontal and inclined layout of anchor cables are designed and completed. The seismic deformation and acceleration amplification characteristics of the slope are compared and analyzed under different arrangement angles of anchor cable, as well as the stress characteristics of the pile-anchor structure. It is revealed the influences of arrangement angle of anchor cable change the seismic seismic performance of the anti-slide pile of prestressed anchor cable-slope system. The results show that there is an abnormal amplification phenomenon of acceleration near the anchor point of the anchor cable under different arrangement angles of anchor cable, and the amplification coefficient increases with the increase of input seismic intensity. The settlement amplitude and acceleration amplification of the slope are significantly reduced when the inclined anchor placement is applied. The inclined anchor placement is beneficial for improving the seismic stress on the pile, and the peak dynamic bending moment and dynamic soil pressure of the pile are significantly reduced compared to those under horizontal anchor placement. The inclined anchoring method can effectively slow down the growth of internal forces in anchor cables and reduce the risk of seismic failure in the pile-anchor-slope system.