Abstract: In order to study the seismic response laws of a semi-underground LNG storage tank and the influences of pile foundation on its seismic performance, a dynamic centrifugal model test is designed and carried out. By comparing the acceleration, swing angle and liquid slosh wave height of pile and non-pile tanks under earthquake, the improvement effects of pile foundation on the seismic performance of the semi-underground LNG storage tank are discussed. The results show that the experimental design method for the large LNG storage tank centrifuge with natural vibration period as the control parameter meets the design principles and requirements. Under the loadings of El Centro waves of 0.05g, 0.1g and 0.3g, the pile foundation reduces the horizontal acceleration of 5.0%~36.6%, the maximum swing angle of 13.8%~33.6% and the slosh wave height of 8.4%~18.8%. The pile foundation is beneficial to improve the seismic performance of semi-underground LNG storage tank.