Abstract: Methane hydrate (MH) has been attracting extensive attention as one of the most potential clean energy sources. During exploitation, hydrate dissociation induces the weakening of mechanical properties of near-well MH bearing sediments (MHBS), which can result in series of engineering problems. Given that most current researches didn’t focus on the interface properties of MHBS-well structure during exploitation, in this paper, the practical multi-field TOUGH+HYDRATE+ PFC coupling framework is adopted, considering different conditions of a more real MHBS-well interface, the multi-field coupling numerical simulation of depressurization is performed, comparation and analysis are made on mechanical properties of near-well soil and the well, and the influence of surface roughness on wellbore stability is discussed. The results show that: (1) Different well roughness doesn’t have obvious influence on the thermal-mechanical-chemical evolution and production efficiency. (2) Appropriately increasing the surface roughness of the well can effectively reduce the settlement amplitude of the soil in contact area and enhance the stability of soil in the contact area of the wellbore, reduce the risk to ensure a relatively stable long-term production. (3) The increase of well roughness will lead to greater frictional force on the well. It is necessary to control the well surface not to be too rough, in order to prevent the wellbore itself from suffering the impact of excessive forces, losing stability and becoming failure.