Abstract: As an important part of the urban underground infrastructure, the underground structures such as subway stations will cause great economic damage and casualties once they are subjected to earthquakes and earthquake-induced fires. Therefore, the catastrophic behaviors of the subway stations under the coupling of earthquakes and earthquake-induced fires needs to be studied. A two-dimensional analysis model is established based on a three-span two-story subway station. Firstly, the seismic simulation is carried out, and then the restart analysis is used to discuss the response of the subway station under the action of earthquake and the secondary fire by using the thermal-mechanical coupling method. The catastrophic behaviors of the subway station structure under earthquake and the secondary fire is analyzed from the aspects of column deformation and inter-layer displacement. The influences of earthquake on the fire resistance of the underground structures are discussed, which provides a reference for the performance evaluation of the underground structures under earthquakes and the secondary fire.