Abstract: In order to reveal the mechanism of the progressive failure of sensitive clay slopes, the Saint-Jude landslide in Canada is used as a research case, and the Eulerian approach under the coupled Eulerian-Lagrangian (CEL) framework is used to carry out the numerical simulation. The research results show that: (1) The topography of the Saint-Jude landslide obtained by the CEL numerical simulation is basically consistent with the field surveyed one. (2) The CEL numerical simulation method can effectively simulate the sensitive clay landslides from the initial instability failure to the subsequent progressive failure, and the progressive failure mode of the Saint-Jude landslide can be truly simulated. (3) The CEL numerical simulation method effectively captures the characteristics of shear stress during the progressive failure of the sensitive clay slope, thereby revealing the mechanism of progressive failure of sensitive clay slopes.