Abstract: The dynamic centrifugal model tests on the loess slope samples with geometric scale of 1∶20, which are taken from a typical slope in Lanzhou, are designed and carried out. The characteristics of seismic dynamic response, stability and deformation of the loess slope are studied systematically. The results show that the acceleration amplification effect of the loess slope increases nonlinearly with the slope height and reaches the maximum at the top of the slope. Under the action of strong earthquakes, the failure of the loess slope shows that there is obvious subsidence at the top of the slope, and a large number of fractures and fissures appear at the shallow stratum, shoulder and slope surface. Due to the seismic subsidence deformations at the shoulder and surface of the slope and the development of the fractures and fissures in the slope, uplift deformation appears at the middle and lower parts of the slope, and they move towards the direction of the slope surface. The potential slip surface is formed by the development of fractures and fissures in the slope, which provides the conditions for the overall slip of the slope.