Abstract: Chemical explosion in rock mass is an important method to study the seismic coupling effects, but the characteristics of rock near the explosive always change or the propagation path of seismic waves always changes, which will bring bad quality of seismic waves and higher engineering cost. An antiknock structure and its design method are presented to solve this problem, in which the steel fiber-reinforced concrete is lined, and the experiments can be reduplicated. The numerical simulation is performed on predicting the high-risk location of structural damages and the fracture modalities. Then, a structural design project is established in allusion to the simulated results. In this closed facility, the chemical experiments with TNT charge of hundreds of kiloliters magnitude are carried out repeatedly. Through the comparisons of damages on wall after bursting, borehole sampling and borehole observation, it is confirmed that multiple explosions have no obvious effects on the lining interface. The seismic signals of similar events in the same placement show good stability and repeatability, which confirm that the blast resistant structure has achieved the expected design objective. This work may be provided as an engineering case or technical reference.