Abstract: The seismic response of transfer station structure is worthy of attention due to its significant spatial effects and importance in the underground network. A three-dimensional computational analysis model is established, in which the transfer station structure is simplified into a cross-shaped structure composed of two frame structures with identical length and structural form, and the equivalent linear model Davidenkov model is employed to consider the nonlinear model of soil. The seismic response of the transfer station structure is calculated under different seismic wave amplitudes and types. At the same time, the spatial effect is analyzed by comparing the seismic response of the transfer station structure with that of a typical subway station. Based on the calculated results, it is shown that the overall seismic performance of the transfer station structure is better than that of a single station due to the influence of its end walls, and its spatial effect is stronger and its relative deformation is smaller. The transfer station blocks the transmission of seismic waves to a certain extent because of its relatively large size. Therefore, the existence of the transfer station reduces site soil acceleration significantly, while the single station amplifies the response of soil surface. The research results can provide some references for the seismic design and analysis of transfer station structures.