Abstract: Based on the actual project and the Geostudio analysis software, the dynamic analysis model for a multistage high slope reinforced by frame structure with pre-stressed anchors is established. By inputting the horizontal seismic action and setting the boundary conditions, the responses of displacement, velocity, acceleration and axial force of anchors are analyzed. The results show that under the effect of horizontal earthquake, the displacement, velocity, acceleration and axial force of anchors of the slope have fluctuating change over the time of earthquake action. The horizontal displacement changes significantly and has an accumulation effect, and the horizontal displacement of slope is greater than the vertical one. The acceleration amplitude of slope surface increases obviously, which indicates that the surface of slope has an amplification effect on the earthquake acceleration. The total stress increases along the slope height, and it reaches the maximum at the bottom of slope. The axial forces of the free segment and anchorage segment fluctuatly change over the time, and the axial force of the free segment is larger, while that of the anchorage body gradually declines along the direction away from the free segment. The results can provide a reference for multistage high slopes reinforced by frame structure with pre-stressed anchors under earthquake action.