Abstract: Based on the FLAC^3D software, by modifying the cable unit and improving the shear stress extraction method, a numerical model for anchored rock slopes with weak interlayer is established. The influences of anchorage parameters on the distribution of shear stress at the anchorage interface of rock slopes with weak interlayer under earthquakes are analyzed. The results show that the thickness of mortar layer increases, the debonding length of mortar-rock interface increases, and the debonding length of bolt-mortar interface decreases. The cross-sectional area of bolts increases, the shear stress at anchorage interface transfers towards the head and roots of bolts, and the debonding length increases. Properly increasing the length of anchorage section and reducing the spacing between the bolts are beneficial to slope stability. Under a certain anchorage length, the anchorage angle should be increased appropriately. The influences of anchorage parameters on the distribution of shear stress and the anchorage mechanism of the anchorage interface under seismic condition are revealed. It is of important reference value for the design and construction of slope anchorage.