Abstract: The main canal of the middle route of South to North Water Diversion Project for 1st class projects belong to over-sized of the water conveyance project, the canal section of the design flow rate of 285 m³/s~ 265 m³/s, increase the flow rate of 345 m³/s-320 m³/s. According to the middle route of Zhengzhou 1st section of terrain and meteorological , horological geology condition, main-canal seepage control and drainage design for the targeted research, calculation and design, puts forward a complete set of design thinking and scheme, so far the middle route of Zhengzhou 1st section of main canal running in good condition, show that the reliability and superiority of design scheme, for the following as a reference for the design of large water main canal.