Abstract: A large scale shaking table test on slope reinforced by double-row anti-slide piles and pre-stressed anchor cables is designed. The results show that change of axial force of anchor cables reflects the development of slope stability. Under the effect of small earthquake, the anchor cables do not start to work, and with the disturbance of earthquake, the prestress of pre-stressed anchor cables decreases. When the amplitude of input earthquake increases, because of the local instability in slope shoulder part, the anchor cables will begin to bear load and the axial force increases until the whole slope has instability trend. Under this condition, all the anchor cables will start to bear load and axial force increase, then a new balance will be developed and due to the disturbance of earthquake, the prestress of all anchor cables will continue to decrease in the new balance. In the test, the maximum prestress loss ratio is 16.28%, so the initial prestress value should be 1.2 times the designed value. In the part over the middle anti-slide pile, the peak value of dynamic response of anchor cable No. 2 is the largest. In the part between middle anti-slide pile and anti-slide pile in the toe of slope, the peak value of dynamic response of anchor cable No. 7 is the largest, and the peak values of anchor cables, No. 4, 5, 6 increase with the increasing elevation. Under the same loading condition, the occurrence time of peak of dynamic response value of all anchor cables is close, and it will be shorter when the input seismic wave amplitude increases. It is near that of input seismic wave. In the design process of pre-stressed anchor cables, the idea of zoning should be adopted, that is to say, the condition, the occurrence time of peak of dynamic response value of all anchor cables is close, and it will be shorter when the input seismic wave amplitude increases. It is near that of input seismic wave. In the design process of pre-stressed anchor cables, the idea of zoning should be adopted, that is to say, the design of the pre-stressed anchor cables in different zones should be based on the different dynamic response laws.