Abstract: The groundwater pollution by organic contaminants is becoming more and more severe, making groundwater remediation be imperative. The researches on the remediation technology are of theoretical and practical importance. Based on the review of in-situ groundwater remediation technology for organic contaminants and micro-nano bubble MNBs technology, MNB technology is proposed for groundwater remediation. The scheme using MNB for in-situ groundwater remediation is introduced. The contaminants can be removed by biodegradation enhanced by MNB. The numerical simulation results of in-situ application show a great enhancement on dissolved oxygen and a significant influence zone for contaminant removal. The MNB technology is effective, energy-efficient and environment-friendly to clean up contaminants, which has great potential in groundwater remediation.