Abstract: Grouting is the important technical means to solve the leakage problem, and the grouting material is the core of sealing technology. The slurries which do not react with water are generally used, such as cement slurry, cement paste slurry, quick-setting paste slurry, hot asphalt and low-thermal asphalt. A flow-water sealing model with a single channel macro-pore for the grouting material which does not react with water is established, based on the rheological properties of grouting slurry, diffusion in the macro-pore, sealing mechanism and grouting parameters. And then the sealing effect and efficiency of different slurries for the stratum with different flow velocities and gap-openings are simulated and calculated. The results can be used in the choice of the grouting slurries which do not react with water for the sealing engineering.