Abstract: In order to investigate the protection process of prestressed anchors with lattice beams in landslide protection as well as their force and deformation rules, the process of prestressed anchors from prestressing to failure is simulated through large-scale physical model tests. The study shows that the landslide protection effect of prestressed anchors can be divided into two stages, active and passive protection stages. At the active protection stage, the force of each anchor is equal. But at the passive protection stage, the force of the lower anchors is stronger than that of the upper ones. The phenomenon is more obvious with the development of landslide. The anchors are in a state of bending and tensile stress during the process of landslide development. The deformation of anchored section near the sliding surface is tensioned in the upside and compressed in the bottom side. But for the free section, it is the opposite. The maximum axial strain of the anchors appears at the anchored section near the sliding surface. In the anchorage section, the axial strain decreases gradually from the sliding surface to the end of the anchors while it is equal in the free section. The bending deformation of anchors in the upper rows is greater than that in the middle and lower rows while the axial tension is opposite.