Abstract: Valley terrain is one of the most important factors which affect the stress and deformation of CFRDs. Different valley terrains lead to different boundary conditions of CFRDs and further influence the state of stress and deformation. 3D-FEM is employed to analyze the stress and deformation of a super-high CFRD 256 m in height under complex topography. It is indicated that the asymmetric and irregular river valley has large influence on the stress and deformation coordination of CFRD, especially the change of stress and deformation gradient is larger near the ancient river terraces at the right bank, which is harmful to the safety of the concrete slab, and thus it is necessary to take measures during design and construction. By comparing the results of two adjustment schemes, the influence of the ancient riverbed on the right bank is analyzed. At the same time, the steep slope at the left bank causes the tensile stress of panel and large displacement of peripheral joints. Based on the results of three adjustment schemes, the influence degree of the steep bank slope is analyzed.