Abstract: Promoted by the rapid development of urban rail traffic in China, more and more cases of underground structures, such as tunnels, have crossed the surface buildings with very close distance. As to the intersecting project, much attention has been paid to the influence of dynamic construction of underground structures on the safety of the adjacent surface buildings, but that on the seismic response of the adjacent surface buildings is usually neglected. Based on a practical project, a coupled interaction calculation model for tunnel-soil-adjacent frame structure is established, and the influence of the tunnel and frame structures on their seismic response is analyzed. The calculation and analysis show that: (1) a seismic response enlarged zone occurs on soil surface; (2) the underlying tunnel has influence on the seismic response of the frame structures, but the influence extent is small; (3) the influence of the frame structures on the underlying tunnel is very small, which can be neglected. The research results may provide references for the planning of underground structures and the seismic design of surface buildings and underground structures.